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Micronized estradiol helps maintain and build your uterine lining so that the transferred embryos will find a comfortable environment there.
Progesterone is used to thicken your endometrium (lining of the uterus) so that the implantation of fertilized egg(s) will be easier. Medications used in ovarian stimulation can suppress progesterone levels in your body, so it is important to supplement it with exogenous progesterone. Progesterone is taken either vaginally (in the case of Prometrium) or as intramuscular injection (in the case of Progesterone in oil).
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